His compatriot David Ferrer will also be present at this stage of the competition after beating with difficulty the Australian 6-2 6-2 4-6 Matthew Ebden.
Scot Andy Murray, seeded number two in the tournament, has not dragged on its side on the court by having snapped the American Alex Bogomolov 6-1 6-2.
Results (number of seeded above the name):
2-Andy Murray (GB) bt Alex Bogomolov Jr. (EU) 6-1 6-2
1-Rafael Nadal (Esp) bt Milos Raonic (Can) 7-5 6-3
3-David Ferrer (Esp) bt Matthew Ebden (AUS) 4-6 6-2 6-2
Santiago Giraldo (Col) bt Dmitry Tursunov (Rus) 6-4 7-6 (4)